Common herb has flavonoids that fight flu virus

A commonly used Chinese herb for cold and fever contains ingredients that can fight influenza viruses, a study in China suggests.

Elsholtzia rugulosa (野拔子 ye ba zi), a common Chinese herb, is widely used in the treatment of cold and fever. A group of researchers of the Chinese Academy of Medical Sciences and Peking Union Medical College, as well as University of Macau investigated the anti-flu functions of the ingredients of this plant.
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In order to elucidate the action mechanism and the active principles from the plant against anti-influenza virus, the influenza virus neuraminidase (NA) activity assay and in vitro antiviral activity assay were established, and the isolation of the active principles was guided by NA activity.

Their study established that five active constituents were found in ye ba zi and they are all flavonoids.

What are flavonoids? Flavonoids (or bioflavonoids) are a class of plant secondary metabolites fulfilling many functions including producing yellow or red/blue pigmentation in flowers and protection from attack by microbes and insects. The widespread distribution of flavonoids, their variety and their relatively low toxicity compared to other active plant compounds (for instance alkaloids) mean that many animals, including humans, ingest significant quantities in their diet. Flavonoids have been referred to as “nature’s biological response modifiers” because of strong experimental evidence of their inherent ability to modify the body’s reaction to allergens, viruses, and carcinogens. They show anti-allergic, anti-inflammatory, anti-microbial and anti-cancer activity.

Consumers and food manufacturers have become interested in flavonoids for their medicinal properties, especially their potential role in the prevention of cancers and cardiovascular disease. The beneficial effects of fruit, vegetables, and tea or even red wine have been attributed to flavonoid compounds rather than to known nutrients and vitamins.

The five constituents are:

1. apigenin
2. luteolin
3. apiin
4. galuteolin
5. luteolin 3′-glucuronyl acid methyl ester

According to the researchers, these constituents all possessed anti-influenza virus activity. Among them, apigenin and luteolin exhibited the highest activities against influenza virus (H3N2).

What is apigenin? Apigenin is described as a nonmutagenic bioflavonoid which is presented in leafy plants and vegetables (e.g., parsley, artichoke, basil, celery) and has significant chemopreventive activity against UV-radiation. Current research trials indicate that it may reduce DNA oxidative damage; inhibit the growth of human leukemia cells and induced these cells to differentiate; inhibit cancer cell signal transduction and induce apoptosis (cell death); act as an anti-inflammatory; and as an anti-spasmodic or spasmolytic.

Apigenin is also reported to be useful in fighting against antiestrogen-resistant breast cancer.

Apigenin is a bioflavone, considered to have a bioactive effect on human health as antioxidant, radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, immunity system modulater.

What is luteolin? Luteolin is a flavonoid thought to play an important role in the human body as an antioxidant, a free radical scavenger, an agent in the prevention of inflammation, a promoter of carbohydrate metabolism, and an immune system modulator. These characteristics of luteolin are also believed to play an important part in the prevention of cancer. Multiple research experiments describe luteolin as a biochemical agent that can dramatically reduce inflammation.

Luteolin inhibited the excess production of TNF-alpha, which directly causes inflammation and apoptosis. Luteolin also offers hope to develop a novel type of anti-inflammatory and anti-allergic drugs.

Luteolin is most often found in leaves, but it is also seen in rinds, barks, clover blossom and ragweed pollen. It has also been isolated from Salvia tomentosa. Dietary sources include celery, green pepper, perilla and camomile tea.

Discrimination May Lead to Smoking in Boys

FRIDAY, Jan. 22 (HealthDay News) — Minority teen boys smoke more when they suffer discrimination, but that’s not the case for minority teen girls, a U.S. study finds.

Perceived discrimination had no effect on smoking rates among minority girls aged 12 to 15 and was associated with lower rates of smoking among minority teen girls aged 16 to 19.

“Our findings in girls, especially in the older girls, really surprised us,” study first author Dr. Sarah Wiehe, an assistant professor of pediatrics at the Indiana University School of Medicine, said in a news release from the school. “We do not know why older girls who perceived discrimination were less likely to smoke, but there may be a possibility that they perceived discrimination because they were pregnant and also that they did not smoke due to pregnancy.”

The study included 2,561 black and Hispanic teens, aged 12 to 19, living in low-income households in Baltimore, Boston, Chicago, Los Angeles and New York. About 25% of the teens reported discrimination within the previous six months, and 12% said they’d smoked within the previous 30 days.

Increased smoking by boys who suffer higher levels of discrimination may be caused by increased stress from male-specific targeting by police and business, the study concluded.

“Boys and girls may experience discrimination differently due to where they spend their time and that may account for the differences in whether discrimination was associated with smoking,” Wiehe said. “In other words, the context of discrimination matters. We need to be aware that discrimination is a public health problem for adolescents — one related to major health issues like smoking — and need to actively work to reduce these occurrences.”

The study appears online and in the March print issue of the American Journal of Public Health

Generic Drug for Enlarged Prostate Approved

By Kathleen Doheny
WebMD Health News

Reviewed By Louise Chang, MD

March 2, 2010 — The first generic version of Flomax, a medication to treat the signs and symptoms of an enlarged prostate gland, has won the approval of the FDA.

The generic version of Flomax, known as tamsulosin, will be made by IMPAX Laboratories of Haywood, Calif. Under FDA regulations, the generic versions must meet the same standards as the brand name drug, says Gary Buehler, director of the FDA Office of Generic Drugs, in a news release.

Enlargement of the prostate gland, a condition known as benign prostatic hyperplasia (BPH), is common among men as they age. More than half of men 60 and older and more than 90% of those 70 and older have BPH symptoms, including a weak urine stream, leaking or dribbling, frequent need to urinate at night, and urinary urgency.

The condition is not cancerous.

The prostate is a walnut-shaped gland located just below the bladder. It produces fluid for semen. But when it grows too big, the prostate puts pressure on the urine-carrying canal or urethra, which passes through the prostate, and this can result in the urinary symptoms.

According to information on the Flomax web site, the drug works by relaxing muscles in the prostate and in the neck of the bladder. Somewhat like releasing a pinched straw, it is then easier for urine to pass out of the body.

Those taking the drug are cautioned to avoid hazardous tasks or driving until they know how the drug affects them. Commonly reported side effects include a runny nose, dizziness, and a decrease in semen, although the drug is not linked with a decrease in sex drive nor impotence.

ED, Heart Disease May Be Deadly Duo

By Bill Hendrick
WebMD Health News

Reviewed by Laura J. Martin, MD
Latest Mens Health News

* ED, Heart Disease May Be Deadly Duo
* Drug for Enlarged Prostate Approved
* Discrimination May Lead to Smoking in Boys
* Men in Europe Trace Roots to Near East Migrants
* Women’s Scent Triggers Hormone Surge in Men
* Want More News? Sign Up for MedicineNet Newsletters!

March 15, 2010 — Erectile dysfunction is a major warning sign for cardiovascular disease and early death.

The finding comes from placebo-controlled studies comparing randomly selected men with ED and cardiovascular disease and men without ED.

The men with ED and cardiovascular disease were:

* 1.9 times more likely to die from cardiovascular disease
* Twice as likely to have a heart attack
* 1.2 times more likely to be hospitalized for heart failure
* 1.1 times more likely to have a stroke

The researchers say they found that medications like ramipril, an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure and heart failure, can reduce cardiovascular events but don’t seem to influence the course or development of ED.

“Erectile dysfunction is something that regularly should be addressed in the medical history of patients,” Michael Bohm, MD, lead author of the study and chairman of internal medicine at the University of Saarland in Germany, says in a news release. “It might be a symptom of early atherosclerosis.”

The study included 1,549 male cardiovascular patients in 13 countries. Each was asked if he had ED, and men who answered in the affirmative were then categorized as having mild, mild-to-moderate, moderate, or severe ED. The average follow-up was five years.

Patients in one trial involving 400 men were randomly assigned to take ramipril, telmisartan — an angiotensin II receptor antagonist used to treat hypertension and heart failure — or a combination.

In another, ACE inhibitor-intolerant patients were randomly assigned to take a placebo or telmisartan.

Patients with ED were older and had a higher prevalence of hypertension, stroke, diabetes, and lower urinary track surgery than men without ED. And 55% of men had ED when they entered the trials.

Researchers say deaths from all causes occurred in 11.3% of patients who had ED at the start, but in only 5.6% of people with no ED or only mild problems at baseline.

They report that 16.2% of ED patients died from cardiovascular problems, suffered heart attacks or strokes, or were hospitalized for heart failure. Only 10.3% of men with no or mild ED had similar outcomes.

As ED worsened, risk of death from all causes increased, suggesting that ED identifies men whose cardiovascular disease might be dangerously advanced.

Bohm says that ED is closely associated with conditions that occur in atherosclerosis and vascular problems, such as plaque buildup, which often precedes heart attacks and strokes.

“Men with ED going to a general practitioner or a urologist need to be referred for a cardiology workup to determine existing cardiovascular disease and proper treatment,” Bohm says. “ED is an early predictor of cardiovascular disease.”

Men with ED are often treated for impotence but not underlying cardiovascular disease, he says, thus placing “a whole segment of men” at increased risk of death.

Therefore, men and their doctors need to view ED as a risk factor, just as they do high blood pressure and cholesterol, he says.

The study is published in the March 15 issue of Circulation: Journal of the American Heart Association.

Hives

Hives (urticaria) are skin reactions that appear as itchy swellings and can occur on any part of the body. Hives can be caused by an allergic reaction, such as to a food or medication, but they also may occur in non-allergic people. Typical hive symptoms are:

* Raised red welts
* Intense itching

Allergic Eczema

Allergic eczema (atopic dermatitis) is an allergic rash that is usually not caused by skin contact with an allergen. This condition is commonly associated with allergic rhinitis or asthma and features the following symptoms:

* Itching, redness, and or dryness of the skin
* Rash on the face, especially children
* Rash around the eyes, in the elbow creases, and behind the knees, especially in older children and adults (rash can be on the trunk of the body)

Allergic Rhinitis, Asthma, Allergic Eyes

Allergic rhinitis (“hay fever”) is the most common of the allergic diseases and refers to seasonal nasal symptoms that are due to pollens. Year round or perennial allergic rhinitis is usually due to indoor allergens, such as dust mites, animal dander, or molds. It can also be caused by pollens. Symptoms result from the inflammation of the tissues that line the inside of the nose (mucus lining or membranes) after allergens are inhaled. Adjacent areas, such as the ears, sinuses, and throat can also be involved. The most common symptoms include:

* Runny nose
* Stuffy nose
* Sneezing
* Nasal itching (rubbing)
* Itchy ears and throat
* Post nasal drip (throat clearing)

In 1819, an English physician, John Bostock, first described hay fever by detailing his own seasonal nasal symptoms, which he called “summer catarrh.” The condition was called hay fever because it was thought to be caused by “new hay.”

Asthma

Asthma is a breathing problem that results from the inflammation and spasm of the lung’s air passages (bronchial tubes). The inflammation causes a narrowing of the air passages, which limits the flow of air into and out of the lungs. Asthma is most often, but not always, related to allergies. Common symptoms include:

* Shortness of breath
* Wheezing
* Coughing
* Chest tightness

Allergic Eyes

Allergic eyes (allergic conjunctivitis) is inflammation of the tissue layers (membranes) that cover the surface of the eyeball and the undersurface of the eyelid. The inflammation occurs as a result of an allergic reaction and may produce the following symptoms:

* Redness under the lids and of the eye overall
* Watery, itchy eyes
* Swelling of the membranes

Who is at risk and why?

Allergies can develop at any age, possibly even in the womb. They commonly occur in children but may give rise to symptoms for the first time in adulthood. Asthma may persist in adults while nasal allergies tend to decline in old age.

Why, you may ask, are some people “sensitive” to certain allergens while most are not? Why do allergic persons produce more IgE than those who are non-allergic? The major distinguishing factor appears to be heredity. For some time, it has been known that allergic conditions tend to cluster in families. Your own risk of developing allergies is related to your parents’ allergy history. If neither parent is allergic, the chance that you will have allergies is about 15%. If one parent is allergic, your risk increases to 30% and if both are allergic, your risk is greater than 60%.

Although you may inherit the tendency to develop allergies, you may never actually have symptoms. You also do not necessarily inherit the same allergies or the same diseases as your parents. It is unclear what determines which substances will trigger a reaction in an allergic person. Additionally, which diseases might develop or how severe the symptoms might be is unknown.

Another major piece of the allergy puzzle is the environment. It is clear that you must have a genetic tendency and be exposed to an allergen in order to develop an allergy. Additionally, the more intense and repetitive the exposure to an allergen and the earlier in life it occurs, the more likely it is that an allergy will develop.

There are other important influences that may conspire to cause allergic conditions. Some of these include smoking, pollution, infection, and hormones.

What are common allergic conditions and their symptoms and signs?

The parts of the body that are prone to react to allergies include the eyes, nose, lungs, skin, and stomach. Although the various allergic diseases may appear different, they all result from an exaggerated immune response to foreign substances in sensitive people. The following brief descriptions will serve as an overview of common allergic disorders.

What causes allergies?

To help answer this question, let’s look at a common household example. A few months after the new cat arrives in the house, dad begins to have itchy eyes and episodes of sneezing. One of the three children develops coughing and wheezing, especially when the cat comes into her bedroom. The mom and the other two children experience no reaction whatsoever to the presence of the cat. How can we explain this?

The immune system is the body’s organized defense mechanism against foreign invaders, particularly infections. Its job is to recognize and react to these foreign substances, which are called antigens. Antigens are substances that are capable of causing the production of antibodies. Antigens may or may not lead to an allergic reaction. Allergens are certain antigens that cause an allergic reaction and the production of IgE.

The aim of the immune system is to mobilize its forces at the site of invasion and destroy the enemy. One of the ways it does this is to create protective proteins called antibodies that are specifically targeted against particular foreign substances. These antibodies, or immunoglobulins (IgG, IgM, IgA, IgD), are protective and help destroy a foreign particle by attaching to its surface, thereby making it easier for other immune cells to destroy it. The allergic person however, develops a specific type of antibody called immunoglobulin E, or IgE, in response to certain normally harmless foreign substances, such as cat dander. To summarize, immunoglobulins are a group of protein molecules that act as antibodies. There are five different types; IgA, IgM, IgG, IgD, and IgE. IgE is the allergy antibody.

(In 1967, the husband and wife team of Kimishige and Teriko Ishizaka detected a previously unrecognized type of immunoglobulin in allergic people. They called it gamma E globulin or IgE.)

In the pet cat example, the dad and the youngest daughter developed IgE antibodies in large amounts that were targeted against the cat allergen, the cat dander. The dad and daughter are now sensitized or prone to develop allergic reactions on subsequent and repeated exposures to cat allergen. Typically, there is a period of “sensitization” ranging from months to years prior to an allergic reaction. Although it might occasionally appear that an allergic reaction has occurred on the first exposure to the allergen, there must have been a prior contact in order for the immune system to be poised to react in this way.

IgE is an antibody that all of us have in small amounts. Allergic persons, however, produce IgE in large quantities. Normally, this antibody is important in protecting us from parasites, but not from cat dander or other allergens. During the sensitization period, cat dander IgE is being overproduced and coats certain potentially explosive cells that contain chemicals. These cells are capable of causing an allergic reaction on subsequent exposures to the dander. This is because the reaction of the cat dander with the dander IgE irritates the cells and leads to the release of various chemicals, including histamine. These chemicals, in turn, cause inflammation and the typical allergic symptoms. This is how the immune system becomes exaggerated and primed to cause an allergic reaction when stimulated by an allergen.

On exposure to cat dander, the mom and the other two children produce other classes of antibodies, none of which cause allergic reactions. In these non-allergic members of the family, the dander particles are eliminated uneventfully by the immune system and the cat has no effect on them.

What does an allergy mean?

An allergy refers to an exaggerated reaction by our immune system in response to bodily contact with certain foreign substances. It is exaggerated because these foreign substances are usually seen by the body as harmless and no response occurs in non- allergic people. Allergic people’s bodies recognize the foreign substance and one part of the immune system is turned on. Allergy-producing substances are called “allergens.” Examples of allergens include pollens, dust mite, molds, danders, and foods. To understand the language of allergy it is important to remember that allergens are substances that are foreign to the body and can cause an allergic reaction in certain people.

When an allergen comes in contact with the body, it causes the immune system to develop an allergic reaction in persons who are allergic to it. When you inappropriately react to allergens that are normally harmless to other people, you are having an allergic reaction and can be referred to as allergic or atopic. Therefore, people who are prone to allergies are said to be allergic or “atopic.”

Austrian pediatrician Clemens Pirquet (1874-1929) first used the term allergy. He referred to both immunity that was beneficial and to the harmful hypersensitivity as “allergy.” The word allergy is derived from the Greek words “allos,” meaning different or changed and “ergos,” meaning work or action. Allergy roughly refers to an “altered reaction.” The word allergy was first used in 1905 to describe the adverse reactions of children who were given repeated shots of horse serum to fight infection. The following year, the term allergy was proposed to explain this unexpected “changed reactivity.”

Allergy Fact

* It is estimated that 50 million North Americans are affected by allergic conditions.
* The cost of allergies in the United States is more than $10 billion dollars yearly.
* Allergic rhinitis (nasal allergies) affects about 35 million # Americans, 6 million of whom are children.
# Asthma affects 15 million Americans, 5 million of whom are children.
# The number of cases of asthma has doubled over the last 20 years.

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